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CAR is strongly expressed in brain and heart during embryonic development and becomes down-regulated in early postnatal stages.Cell adhesion experiments, binding studies and as well as crystallographic investigations on the extracellular domain reveal a flexible ectodomain for CAR that mediates homophilic and heterophilic binding.( Location of CAR in the embryonic (E15) and mature murine heart (adult).At embryonic stages CAR is uniformly localized on the plasma membrane of cardiomyocytes.You simply can not get access to this incredible HD content anywhere else!

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